Alpha-Lipoic Acid by Dr. Danielle, Neuropathy Support, Non-GMO, Gluten-Free, Vegan, Soy-Free, Promotes Healthy Blood Sugar, Alpha R Lipoic Acid R-ALA, R-ALA, 120 Veggie Caps

Day 6 on RALA Lipoic Acid. So far this has been amazing. The nerves in my feet are not screaming as loud anymore, they have calmed down tremendously. I can feel the synovial fluid in my feet building up and the inflammation in them in greatly decreased. I can actually rotate my feet now and I can flex my feet when walking. It is still painful to put my feet down but that is decreasing as well. My feet feel like they are waking up from a very long sleep.The tightness in my feet and spine is diminishing. I am having to adjust my movements in and around my environment because my movements have been so stiff for so long and now I have flex and freedom. It’s almost feels like I am jello at times but in a good way.My ears have not been producing as much wax, headaches have decreased, swelling in my throat has decreased, memory issues have decreased, disjointed thought patterns have decreased, heart rate is better, and more (all caused by Hashimoto’s disease).Digestive issues are much better. Sleep issue, anxiety, and general mood is much better as well. In a few weeks I will have labs done and I will know more but so far so good.Oh, and my hair and skin look healthier.

No so much effective as shown and advertisedNot recommend to my all Indians

For about 2 months I was suffering daily from extremely uncomfortable nerve pain and buzzing in my groin area. I went to see two urologists, a neurologist, I took two trips to two different hospitals, and I had two MRIs and no one could tell what what was going on. I did have double hernia surgery last Winter and so I visited my surgeon about this as well; but he too had no idea what was going on. I was desperate. I couldn't go to work and I couldn't walk or sit for any length of time. The research I did prior to purchasing suggested this would help.That said, I've been taking this for about 4 days now and this really does seem to be helping with my nerve issues. Today I barely felt any pain or buzzing. I've had a big increase in healing the past 3 days and I have more energy. I should mention I'm also taking this with an L-arginine/L-citruline supplement that I started at the same time, along with Ginko, Lysine, Flaxseed Oil (Omega 3/6), Ceylon Cinnamon, and Centrum Men's (all which I was already taking before the nerve issue started). I'm also started juicing again (highly recommended!) and I'm trying to cut back on dairy and caffeine as best I can; but honestly, I'm not doing so well cutting back on either. Supposedly caffeine and dairy could possibly complicate my issue; however, since I'm doing better, I really don't think that was the issue.So, was this supplement a cure for me? With everything I'm doing, it's hard to say. In a sense, I threw the kitchen sink at this issue because I need to work. But this and the L-arginine/L-citruline supplement are the only new supplements I've been taking. And I've been juicing again which I started about the same time as this supplement (apple, carrot, kale). Since I'm feeling so much better, I'm going to keep doing what I'm doing and not worry about it too much. If it works, it works.One last thing, I did the best I could to make sure I don't mix supplements that could be harmful to me, but I'm no professional. Please educate yourself properly before making any decision regarding your health for your own sake. Best of luck.

My husband has been using this product for several years now to help alleviate his peripheral neuropathy due to diabetes. He was prescribed gabapentin by his physician, but the side effect of blisters on his lower leg sent me searching for another option. Some studies showed that ALA was effective in reducing the neuropathy symptoms, so he slowly weaned himself off the gabapentin and began taking ALA instead. Recommended upper dose limit is 1200 mg, so we slowly added the Dr. Danielle's 550 mg (includes both S-ALA 250 and R-ALA 300) and another brand 600 mg just to save some money, His current regimen is Dr. Danielle's in the am, and the 600 mg. pm, so he's taking 1150 mg total (rationale is that the pain would bother him more at night, so higher dose pm). It's hard to know if the R-ALA in Dr.Danielle's formulation is a factor, but this mix is working extremely well for us without the high powered drug side effects. Although he has developed a few blisters while using the ALA, they have been much smaller and less frequent. Logically, I suspect the ALA targets the same biochemical pathways as gabapentin, but does so with a nudge rather than a sledge hammer. It may also be helping his A1C, He'll continue to take Dr.Danielle's.Cost is reasonable for an R-ALA + S-ALA mix (the other brand is likely just S-ALA - doesn't say on the label).  Dr. Danielle Alpha Lipoic Acid, RALA, Extremely High Quality Alpha R Lipoic Acid (R-ALA)R- ALA 120 CapsulesDr. Danielle Alpha Lipoic Acid, RALA, Extremely High Quality Alpha R Lipoic Acid (R-ALA)R- ALA 120 Capsules

If you read the information I posted below, you will understand why only R-ALA makes sense to take and on an empty stomach. I like this product because it is R-ALA, and the price is reasonable for the dosage of 300mg and the number of capsules. I also like Doctors Best Stabilized R-Lipoic acid, which claims to Feature BioEnhanced™ Na-RALA, a more bioavailable form. Not sure I notice a difference, but it is more expensive, with lower dose and fewer capsules which is why I switched to this one. My favorite ALA product is not sold to the public but through practitioners (doctors, naturopaths, accupuncturists, chropractors) Researched Nutritionals C-RLA Liposomal Vitamin C and R-Lipoic Acid and is very expensive $100 for ten fluid ounces. The dosage is much lower -- two teaspoons with 70 mg's RLA but I feel it immediately. This is the product Dr. Horowitz, the famous Lyme disease physician gives to his patients to stimulate glutathione synthesis and help clear toxins from the infection.If you are new to alpha lipoic acid I suggest you read the material on from the Linus Pauling Institute: http://lpi.oregonstate.edu/infocenter/othernuts/la/Summary: Only the R- isomer is endogenously synthesized and bound to protein: R-LA occurs natural in foods. LA supplements may contain either R-LA or a 50/50 (racemic) mixture of R-LA and S-LA.Dietary and Supplemental Alpha-Lipoic AcidExogenous LA from the diet can be activated with ATP or GTP by lipoate-activating enzyme, and transferred to LA-dependent enzymes by lipoyltransferase (10, 11). Consumption of LA from food has not yet been found to result in detectable increases of free LA in human plasma or cells (3, 12). In contrast, high oral doses of free LA (≥ 50 mg) result in significant but transient increases in free LA in plasma and cells. Pharmacokinetic studies in humans have found that about 30%-40% of an oral dose of LA (a 50/50 mixture of R-LA and S-LA) is absorbed (12, 13). Oral LA supplements are better absorbed on an empty stomach than with food: taking LA with food decreased peak plasma LA concentrations by about 30% and total plasma LA concentrations by about 20% compared to fasting (14). Additionally, the sodium salt of R-LA may be better absorbed than free LA, presumably because of its higher aqueous solubility (15).There may also be differences in bioavailability of the two isomers of LA. After oral dosing with LA, peak plasma concentrations of R-LA were found to be 40%-50% higher than S-LA, suggesting that R-LA is better absorbed than S-LA (12, 14, 16). Following oral administration, both isomers are rapidly metabolized and excreted. Plasma LA concentrations generally peak in one hour or less and decline rapidly (12, 13, 16, 17). In cells, LA is quickly reduced to DHLA, and studies in vitro studies indicate that DHLA is rapidly exported from cells (3).Although LA is a potent antioxidant in the test tube, LA supplementation may affect health by stimulating glutathione synthesis, enhancing insulin signaling, and modulating the activity of other cell-signaling molecules and transcription factors. (More information)Overall, the available research indicates that treatment with 600 mg/day of intravenous LA for three weeks significantly reduces the symptoms of diabetic peripheral neuropathy. (More information)Compared with intravenous administration, the effect of long-term, oral LA supplementation for diabetic peripheral neuropathy is less clear, yet some studies show that oral supplementation with at least 600 mg/day of LA may be beneficial. (More information)If you choose to take LA supplements, the Linus Pauling Institute recommends a daily dose of 200-400 mg/day of LA for generally healthy people.