THORNE - Phosphatidylserine (Formerly Iso-Phos) - Cortisol Management Support - Phosphatidylserine Isolate Supplement to Support Brain Function* - 60 Capsules - 60 Servings

I started using Thorne’s Phosphatidylserine in June 2025, and I’ve now tested it in both calm and high-stress situations. Each time, the effects were consistent and noticeable.This isn’t a sedative and it doesn’t leave you groggy. What it does is take the edge off your nervous system. For me, it showed up as a subtle but powerful calm—enough to quiet racing thoughts so I could process, rest, or simply breathe. The shift is clear without feeling “drugged” or detached.I took it once during the day, and once at night and then again at night following the shocking news of Charlie Kirk’s assassination. Both night times, my baseline was hypervigilance—restless body, mind in overdrive. Within about 30–45 minutes, I could feel my system regulate. It didn’t put me in a trance, but it gave me the mental space to think clearly and relax. Interestingly, when it wore off at night, I woke up and immediately felt my mind racing again, which confirmed to me just how effective it had been while active.Another strength: no hangover effect the next morning. Unlike some calming supplements that leave you foggy, this one leaves you steady and clear. Yes, it’s on the expensive side—but when a product actually does what the science says it should, that value is there.Phosphatidylserine has been studied for its role in cortisol regulation and cognitive resilience- That's something I have looked into, and I can say firsthand: Thorne delivers on that research. I do buy other Thorne products because I value their research and quality (but I have to say it is very expensive to be a fan of Thorne) For anyone dealing with stress, overactive thoughts, or the need to stay clear while calming down, this is worth having in your toolbox. I have recommended it twice to people since this tragic news and loss of life of a well known God fearing public figure.

Basically I hadn't slept in 30 years. I can count on one hand the number of good nights sleep in the past. Tried to sleep at night but always had a wired feeling after 6pm. Long story short, it turns out that I had high cortisol levels at night which kept me awake causing insomnia. Phosphatidylserine reduces cortisol levels and has allowed me to actually sleep for the first time in my life! I take 2 capsules three hours before bedtime then two more capsules one hour before bedtime. I also have restless legs at night which is a secondary problem that wakes me up during the night. Stretching helps a lot, but that, along with Thornes magnesium bisglycinate powder gets rid of it. One scoop an hour before bedtime and if I wake during the night I take another scoop. Remember that insomnia is just a "symptom" to an underlying cause. Treating symptoms is futile, more often than not most symptoms are your body's reaction to a root problem. I also do one 3mg. chewable melatonin before bed as well.

Excellent quality brain supplement. I keep them coming. Thanks!

I have confidence in Thorne products. Although they tend to be more expensive than other products, they seem to be well produced, and I feel confident taking them. Supplements seem to be articles of faith. After all, I am taking them and spending money hoping that they work. Therefore, they work. This product must be working; I remembered to write a review.

Solid product.Easy to swallow.Very noticeable difference.

About me:I have had rough 10+ years of health problems, with insomnia being main problem. I have developed hyperthyroidism and insomnia has ruined my life.My history with this supplement and Phosphatidylserine:I have taken Phosphatidylserine from this brand and pure encapsulations brand for last 10 years. I have tried many brands of this supplement. When I first started to take this stuff, it cured my insomnia and I had amazing good sleep for many years. Maybe 5+ years? This stuff cured my insomnia and I was able to eventually get off sleeping medication that I was on for 15 years by taking this and other sleep stuff. I took 1 capsule of this and also PS Plus by pure encapsulations also every night for about 10 years.Last 5 years problems:I had TBI head injury about 5 years ago when hammer hit my head and continued to take this stuff while recovery from my injury. I thought it was really helping, but I eventually developed hyperthyroidism because my insomnia was bad. I made a bunch of personal changes in diet and exercise and I would get streaks of time of good sleep and periods of bad sleep. This whole time I was blaming it on my hyperthyroidism, etc.I have been honing in on what is causing my problems because recently I get 1-2 hours of sleep per night and suddenly get super bad anxiety when I sleep. Well I read the one negative review of this stuff last night and I realized what I thought is my favorite supplement is actually my worst enemy.Update:I have stopped taking this and don't take any other PS sleep stuff and now I get perfect sleep. I have maybe spent thousands of dollars tracking down my problems with insomnia getting tests, etc. and doing all sorts of weird things to try to get sleep. My worst period of time was 15 days no sleep and I have done this twice. I often go through periods of time of 3-5 days no sleep or very little sleep. I could be world record holder for insomnia. This stuff works well with my wife, but not for me. We are all different.This product caused the work record for insomnia!

Es muy pronto para saber si llena mis expectativas! Pero Thorne es un laboratio muy confiable para mi

When absolutely nothing else worked for my insomnia, I tried this, and I’ve had no regrets since! I’ve been taking this for years and it’s made such a miraculous difference in the quality of my sleep. This product is 100% authentic, it’s the same stuff I bought from my holistic doctors office all those years back!I know $60 feels like a lot of money for a supplement, but I promise it’s worth it! Paying $1/day for a heavenly night of sleep is an amazing trade off! One bottle will last you two months.