Designs for Health SAMe Capsules with B6, B12 + 5-MTHF - 200mg S-Adenosylmethionine Supplement with 5-MTHF (Folate) + Vitamin B12 - Non-GMO + Gluten-Free (30 Capsules)

Good methylation support. I have found Designs for Health products to be high quality and effective. It is the brand that my functional medicine dr uses and recommends.

We did a lot of research - actually a ridiculous amount - to identify the safest, purest, and least likely to cause unwanted side effects. We also asked several doctors about various brands. Designs for Health was consistently mentioned as being the most effective with extremely high quality control. This is particularly important for SAMe because the compounds apparently breakdown quite easily if not manufactured or packaged properly. Our son has been on this for almost 2yrs and it has worked very well.

This supplement has been awesome for my son who has depression/anxiety. It has taken alot of the symptoms away and has also given him energy!!! He also eats healthy and exercises daily so make sure you do this as well because it is very important.

Tested by Consumer Lab, found to be a good supplement (no contamination, dosage is what it is advertised, etc).

I had previously used Nature Made Sam-E and it helped quite a bit. I suffer from chronic pain and at the time I took Nature Made Sam-e it felt like it helped alleviate some of the pain and not stress out so much about it. I don't remember why I stopped taking it but I knew there was one small side effects. Well, I thought that Designs for Health would be better but it did not help me at all. In fact, it caused more constipation and some bloating. The price is outrageous too for the smaller dose (200 mg vs. 400 mg I got from Nature Made brand). So I guess I will go back to Nature Made.