Will this replacement brush heads fit the HX5310 handle

I'm not sure. Our toothbrushes are in the E series and according to the description for these, it "Fits Multiple Sonicare HandlesThe e-Series Standard brush heads work with the following Sonicare models: Advance, Essence, Elite, CleanCare, and Xtreme. "You should be able to go to Phillips Soniare website, and if you can't find the answer there I believe you can email them to find out for sure. Sorry I can't be of more help!

will this work with HX5612? Thanks.

Yes, will fit sonicare HX 5612 Essence model.

I believe it will, they recommend that brush head for the hx5310. My advice is to look up hx5310 on amazon before ordering just to make sure.

Will the brush work with 5100 toothbrush...Thanks?

Hello! We don't have enough information to answer your question. Please get in touch with us so that we can assist you. We look forward to hearing from you! Please call us at 1-800-682-7664 at your earliest convenience so that we can quickly address your issue. We're available Monday - Saturday, 9:00 AM - 9:00 PM EST and on Sundays from 9:00 AM - 6:00 PM EST, excluding major holidays. Or, visit the "Toothbrushes / Sonicare" section of our "Contact Philips" page to chat with us 24/7: https://www.usa.philips.com/content/B2C/en_US/support-home/support-contact-page.html.

Genuine E-Series Replacement Toothbrush Heads, 2 Brush Heads, White, HX7022/66

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